Nucleosides XI. Synthesis and antiviral evaluation of 5′-alkylthio- 5′-deoxy quinazolinone nucleoside derivatives as S-adenosyl-L-homocysteine analogs

Tun Cheng Chien, Chien Shu Chen, Fang Hwa Yu, Ji Wang Chern*

*此作品的通信作者

研究成果: 雜誌貢獻期刊論文同行評審

91 引文 斯高帕斯(Scopus)

摘要

4-Amino-1-(β-D-ribofuranosyl)quinazolin-2-one (3) was prepared by a direct glycosylation of 4-aminoquinazolin-2-one (7) using the Vorbruggen's silylation method and provided exclusively the β-anomer. This quinazoline nucleoside and its 2′,3′-O-isopropylidene derivative (9) did not undergo the coupling reaction with dialkyl disulfides in the presence of tri-n-butylphosphine unless their 4-amino groups were protected by N,N-dimethyl-aminomethylidene. This approach provides a viable alternative synthetic route to 5′-alkylthio-5′-deoxy nucleosides.

原文英語
頁(從 - 到)1422-1426
頁數5
期刊Chemical and Pharmaceutical Bulletin
52
發行號12
DOIs
出版狀態已發佈 - 2004 十二月
對外發佈

ASJC Scopus subject areas

  • 化學 (全部)
  • 藥物發現

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