TY - JOUR
T1 - Nucleosides. IX. Synthesis of Purine N3,5′ -Cyclonucleosides and N3,5′-Cyclo-2′,3′ -seconucleosides via Mitsunobu Reaction as TIBO-like Derivativest
AU - Chen, Grace Shiahuy
AU - Chen, Chien Shu
AU - Chien, Tun Cheng
AU - Yeh, Jun Yen
AU - Kuo, Chia Chi
AU - Talekar, Rahul Subhash
AU - Chern, Ji Wang
PY - 2004
Y1 - 2004
N2 - The Mitsunobu reaction was applied to prepare, in one step, purine N 3,5′-cyclonucleosides 10a-d. A subsequent ring opening in the ribose moiety of the resultant N3,5′-nucleosides by sodium periodate led to the corresponding N3,5′-cyclo-2′ ,3′-seconucleosides. These products consist of 5-, 6-, and 7-membered tricyclic system which is the basic skeleton of TIBO derivatives, known antiviral agents.
AB - The Mitsunobu reaction was applied to prepare, in one step, purine N 3,5′-cyclonucleosides 10a-d. A subsequent ring opening in the ribose moiety of the resultant N3,5′-nucleosides by sodium periodate led to the corresponding N3,5′-cyclo-2′ ,3′-seconucleosides. These products consist of 5-, 6-, and 7-membered tricyclic system which is the basic skeleton of TIBO derivatives, known antiviral agents.
KW - Formycin B
KW - Mitsunobu reaction
KW - N ,5′-cyclo-2′, 3′-seconucleoside
KW - N,5′-cyclonucleoside
KW - TIBO
UR - http://www.scopus.com/inward/record.url?scp=1542679040&partnerID=8YFLogxK
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U2 - 10.1081/NCN-120027904
DO - 10.1081/NCN-120027904
M3 - Article
C2 - 15043159
AN - SCOPUS:1542679040
SN - 1525-7770
VL - 23
SP - 347
EP - 359
JO - Nucleosides, Nucleotides and Nucleic Acids
JF - Nucleosides, Nucleotides and Nucleic Acids
IS - 1-2
ER -