Nucleosides. IX. Synthesis of Purine N3,5′ -Cyclonucleosides and N3,5′-Cyclo-2′,3′ -seconucleosides via Mitsunobu Reaction as TIBO-like Derivativest

Grace Shiahuy Chen, Chien Shu Chen, Tun Cheng Chien, Jun Yen Yeh, Chia Chi Kuo, Rahul Subhash Talekar, Ji Wang Chern*

*此作品的通信作者

研究成果: 雜誌貢獻期刊論文同行評審

15 引文 斯高帕斯(Scopus)

摘要

The Mitsunobu reaction was applied to prepare, in one step, purine N 3,5′-cyclonucleosides 10a-d. A subsequent ring opening in the ribose moiety of the resultant N3,5′-nucleosides by sodium periodate led to the corresponding N3,5′-cyclo-2′ ,3′-seconucleosides. These products consist of 5-, 6-, and 7-membered tricyclic system which is the basic skeleton of TIBO derivatives, known antiviral agents.

原文英語
頁(從 - 到)347-359
頁數13
期刊Nucleosides, Nucleotides and Nucleic Acids
23
發行號1-2
DOIs
出版狀態已發佈 - 2004

ASJC Scopus subject areas

  • 生物化學
  • 分子醫學
  • 遺傳學

指紋

深入研究「Nucleosides. IX. Synthesis of Purine N<sup>3</sup>,5′ -Cyclonucleosides and N<sup>3</sup>,5′-Cyclo-2′,3′ -seconucleosides via Mitsunobu Reaction as TIBO-like Derivativest」主題。共同形成了獨特的指紋。

引用此