摘要
Stereoselective reduction of various α-keto esters 5a-d derived from exo-10,10-diphenyl-2,10-camphanediol 4a and exo-10,10-diphenyl-10-methoxy-2- camphanol 4b is described. High to excellent diastereomeric excess (99% de) with good chemical yields is obtained. The sense of stereoselectivity as a function of C10 modification is remarkable. Further, in the case of 5d, both diastereomers of α-hydroxyl esters can be obtained with excellent optical purity by the appropriate choice of reaction conditions. The influence of the solvents and additives on the reaction course has been investigated.
原文 | 英語 |
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頁(從 - 到) | 6993-6998 |
頁數 | 6 |
期刊 | Journal of Organic Chemistry |
卷 | 64 |
發行號 | 19 |
DOIs | |
出版狀態 | 已發佈 - 1999 9月 17 |
ASJC Scopus subject areas
- 有機化學