Non-invasive and high-sensitivity scanning detection of magnetic nanoparticles in animals using high-Tc scanning superconducting- quantum-interference-device biosusceptometry

J. J. Chieh, C. Y. Hong

研究成果: 雜誌貢獻文章

11 引文 斯高帕斯(Scopus)

摘要

Although magnetic nanoparticles (MNPs) have been widely applied to animals in biomedicine, MNPs within animals should be examined in real time, in vivo, and without bio-damaged possibility to evaluate whether the bio-function of MNPs is valid or to further controls the biomedicinal process because of accompanying complex problems such as MNPs distribution and MNPs biodegradation. The non-invasive and high-sensitivity scanning detection of MNPs in animals using ac susceptometry based on a high-Tc superconducting quantum interference device (SQUID) is presented. The non-invasive results and biopsy results show good agreement, and two gold-standard biomedicine methods, Prussian blue stain and inductively coupled plasma, prove the magnetic results. This confirms that the future clinical diagnosis of bio-functional MNPs could be operated by using scanning SQUID biosusceptometry as conveniently as an ultrasonic probe.

原文英語
文章編號084301
期刊Review of Scientific Instruments
82
發行號8
DOIs
出版狀態已發佈 - 2011 八月 1

ASJC Scopus subject areas

  • Instrumentation

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