NMR assignments of the WBSCR27 protein related to Williams-Beuren syndrome

Sofia S. Mariasina, Olga A. Petrova, Ilya A. Osterman, Olga V. Sergeeva, Sergey V. Efimov, Vladimir V. Klochkov, Petr V. Sergiev, Olga A. Dontsova, Tai huang Huang, Chi Fon Chang, Vladimir I. Polshakov*


研究成果: 雜誌貢獻期刊論文同行評審

3 引文 斯高帕斯(Scopus)


Williams-Beuren syndrome is a genetic disorder characterized by physiological and mental abnormalities, and is caused by hemizygous deletion of several genes in chromosome 7. One of the removed genes encodes the WBSCR27 protein. Bioinformatic analysis of the sequence of WBSCR27 indicates that it belongs to the family of SAM-dependent methyltransferases. However, exact cellular functions of this protein or phenotypic consequences of its deficiency are still unknown. Here we report nearly complete 1H, 15N, and 13C chemical shifts assignments of the 26 kDa WBSCR27 protein from Mus musculus in complex with the cofactor S-adenosyl-l-methionine (SAM). Analysis of the assigned chemical shifts allowed us to characterize the protein’s secondary structure and backbone dynamics. The topology of the protein’s fold confirms the assumption that the WBSCR27 protein belongs to the family of class I methyltransferases.

頁(從 - 到)303-308
期刊Biomolecular NMR Assignments
出版狀態已發佈 - 2018 10月 1

ASJC Scopus subject areas

  • 結構生物學
  • 生物化學


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