In this study, we constructed the multispectral imaging by the reconstruction of spectral reflectance. This reconstruction method was based on natural neighbor interpolation, abbreviated as NNI. The experiments focused on the feasibility of the reconstruction of reflectance spectra with multispectral images, and the experimental targets were divided into two types; paper packages, and portraits. The performance was evaluated in terms of root mean square error (RMSE), color difference (?E), and peak signal-tonoise ratio (PSNR). The experimental results showed that the proposed NNI reconstruction method was able to directly generate target spectra from sRGB channel values accurately. Furthermore, even after rendering under various illuminations, the average of color difference was still within an acceptable range.