The impact of teaching material design for multidisciplinary learning on learning achievement with science and technological university students was examined. The participants were students enrolling in an elective general education course, named Technology and Life Application, at a technological university. The experiment lasted for one semester with a total of 16 weeks. The results revealed that the teaching material design for the four topics, including ultrasonic machining, abrasive jet machining, investment casting, and precision welding machining, significantly enhanced students’ learning achievement. However, the teaching material design for the topics of laser beam machining and electrical discharge machining did not have a significant effect on learning achievement. Therefore, the contents of the teaching materials for the topics of laser beam machining and electrical discharge machining required revisions.