Multi-functional stage-scanning fluorescence micro/nanoscope for single-lipid dynamics

Li Ling Yang, Chia Fen Hsieh, Yi Ren Chang, Jie Pan Shen, Yu Chung Chang, Chia Fu Chou

研究成果: 書貢獻/報告類型會議貢獻

摘要

We combine pulsed laser, supercontinuum radiation source and fast single-photon counting peripherals to obtain a multifunctional micro/nano-scope. This provides us with better spatial and temporal resolution to observe fast dynamics. Performing fluorescence correlation spectroscopy for fast dynamics (<μs) with sub-diffraction limit resolution to observe the initial state of single-lipid dynamics in supported lipid bilayers and living cells is our goal. Lipid raft serves as a platform for recruiting signaling components of effective signal transduction. However, the dynamics of sub-200nm rapidly aggregated lipid rafts are still not elucidated in living cells. We here report our recent progress on the construction of this multi-functional stage-scanning fluorescence micro/nanoscope for single-lipid dynamics study.

原文英語
主出版物標題Single Molecule Spectroscopy and Superresolution Imaging V
DOIs
出版狀態已發佈 - 2012 三月 5
事件Single Molecule Spectroscopy and Superresolution Imaging V - San Francisco, CA, 美国
持續時間: 2012 一月 212012 一月 22

出版系列

名字Progress in Biomedical Optics and Imaging - Proceedings of SPIE
8228
ISSN(列印)1605-7422

其他

其他Single Molecule Spectroscopy and Superresolution Imaging V
國家美国
城市San Francisco, CA
期間12/1/2112/1/22

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

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