Multi-channel squid-based ultra-high-sensitivity in-vitro detections for bio-markers of alzheimer's disease via immunomagnetic reduction

M. J. Chiu, Herng-Er Horng, J. J. Chieh, S. H. Liao, C. H. Chen, B. Y. Shih, C. C. Yang, C. L. Lee, T. F. Chen, Shieh-Yueh Yang, C. Y. Hong, Hong-Chang Yang

研究成果: 雜誌貢獻期刊論文同行評審

29 引文 斯高帕斯(Scopus)

摘要

Via immunomagnetic reduction assay, bio-molecules can be quantitatively detected with the aid of bio-functionalized magnetic nanoparticles, which are used as labeling markers for specific bio-molecules. To achieve an ultra-high sensitivity in the detection of bio-molecules, the superconducting quantum interference device (SQUID) looks very promising as a sensor for the magnetic signal that are related to the concentration of the detected bio-molecules. We had developed a single channel SQUID-based magnetosusceptometer, but for increasing the detection through-put, we have developed a multi-channel SQUID-based magnetosusceptometer. In this work, the design and the working principle of a 4-channel SQUID-based magnetosusceptometer are introduced. By utilizing scanning technology, 4 samples can be logged into a SQUID-based magnetosusceptometer simultaneously. Be noted that only one single SQUID magnetometer has been used in the magnetosusceptometer. The precision and the sensitivity of detecting bio-molecules by using a 4-channel SQUID-based magnetosusceptometer have been investigated. The detected bio-molecules are biomarkers for Alzheimer's disease.

原文英語
文章編號5634078
頁(從 - 到)477-480
頁數4
期刊IEEE Transactions on Applied Superconductivity
21
發行號3 PART 1
DOIs
出版狀態已發佈 - 2011 六月

ASJC Scopus subject areas

  • 電子、光磁材料
  • 凝聚態物理學
  • 電氣與電子工程

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