Monitoring protein-related degeneration of Drosophila eyes with optical coherence tomography

Chia Heng Wu, Cihun Siyong Alex Gong, Min Tsan Su, Meng Tsan Tsai

研究成果: 書貢獻/報告類型會議論文篇章

摘要

Drosophila melanogaster has become an invertebrate genetic model for studies of genes-related diseases and developmental biology. Neurodegenerative diseases such Alzheimer and Parkinson's diseases are health problem and get worse with age. However, the causes and progress of neurodegenerative diseases are still poorly understood. The compound eye of Drosophila demonstrates a heterologous system to investigate neurodegenerative diseases. In this study, we propose to use optical coherence tomography (OCT) for the study of protein-related degeneration of Drosophila eyes. With OCT, the bristles of Drosophila eye can be identified and different mutant Drosophila were scanned with OCT for investigation of progress of protein-related degeneration. From the results, it can be noted that OCT could be a powerful and noninvasive inspection tool for protein-related degenerative diseases.

原文英語
主出版物標題Biomedical Imaging and Sensing Conference
編輯Toyohiko Yatagai, Yoshihisa Aizu, Osamu Matoba, Yasuhiro Awatsuji, Yuan Luo
發行者SPIE
ISBN(電子)9781510619791
DOIs
出版狀態已發佈 - 2018 一月 1
事件Biomedical Imaging and Sensing Conference 2018 - Yokohama, 日本
持續時間: 2018 四月 252018 四月 27

出版系列

名字Proceedings of SPIE - The International Society for Optical Engineering
10711
ISSN(列印)0277-786X
ISSN(電子)1996-756X

會議

會議Biomedical Imaging and Sensing Conference 2018
國家/地區日本
城市Yokohama
期間2018/04/252018/04/27

ASJC Scopus subject areas

  • 電子、光磁材料
  • 凝聚態物理學
  • 電腦科學應用
  • 應用數學
  • 電氣與電子工程

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