MicroRNA Signature Predicts Survival and Relapse in Lung Cancer

Sung Liang Yu, Hsuan Yu Chen, Gee Chen Chang, Chih Yi Chen, Huei Wen Chen, Sher Singh, Chiou Ling Cheng, Chong Jen Yu, Yung Chie Lee, Han Shiang Chen, Te Jen Su, Ching Cheng Chiang, Han Ni Li, Qi Sheng Hong, Hsin Yuan Su, Chun Chieh Chen, Wan Jiun Chen, Chun Chi Liu, Wing Kai Chan, Wei J. ChenKer Chau Li, Jeremy J.W. Chen, Pan Chyr Yang*

*此作品的通信作者

研究成果: 雜誌貢獻期刊論文同行評審

695 引文 斯高帕斯(Scopus)

摘要

We investigated whether microRNA expression profiles can predict clinical outcome of NSCLC patients. Using real-time RT-PCR, we obtained microRNA expressions in 112 NSCLC patients, which were divided into the training and testing sets. Using Cox regression and risk-score analysis, we identified a five-microRNA signature for the prediction of treatment outcome of NSCLC in the training set. This microRNA signature was validated by the testing set and an independent cohort. Patients with high-risk scores in their microRNA signatures had poor overall and disease-free survivals compared to the low-risk-score patients. This microRNA signature is an independent predictor of the cancer relapse and survival of NSCLC patients.

原文英語
頁(從 - 到)48-57
頁數10
期刊Cancer Cell
13
發行號1
DOIs
出版狀態已發佈 - 2008 一月 8

ASJC Scopus subject areas

  • 腫瘤科
  • 細胞生物學
  • 癌症研究

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