TY - JOUR
T1 - Metal organic framework-organic polymer monolith stationary phases for capillary electrochromatography and nano-liquid chromatography
AU - Huang, Hsi Ya
AU - Lin, Cheng Lan
AU - Wu, Cheng You
AU - Cheng, Yi Jie
AU - Lin, Chia Her
N1 - Funding Information:
This study was supported by both Grants NSC-100-2632-M-033-001-MY3 and NSC-101-2113-M-033-002-MY3 from the National Science Council of Taiwan .
PY - 2013/5/24
Y1 - 2013/5/24
N2 - In this study, metal organic framework (MOF)-organic polymer monoliths prepared via a 5-min microwave-assisted polymerization of ethylene dimethacrylate (EDMA), butyl methacrylate (BMA), and 2-acrylamido-2-methylpropane sulfonic acid (AMPS) with the addition of various weight percentages (30-60%) of porous MOF (MIL-101(Cr)) were developed as stationary phases for capillary electrochromatography (CEC) and nano-liquid chromatography (nano-LC). Powder X-ray diffraction (PXRD) patterns and nitrogen adsorption/desorption isotherms of these MOF-organic polymer monoliths showed the presence of the inherent characteristic peaks and the nano-sized pores of MIL-101(Cr), which confirmed an unaltered crystalline MIL-101(Cr) skeleton after synthesis; while energy dispersive spectrometer (EDS) and micro-FT-IR spectra suggested homogenous distribution of MIL-101(Cr) in the MIL-101(Cr)-poly(BMA-EDMA) monoliths. This hybrid MOF-polymer column demonstrated high permeability, with almost 800-fold increase compared to MOF packed column, and efficient separation of various analytes (xylene, chlorotoluene, cymene, aromatic acids, polycyclic aromatic hydrocarbons and trypsin digested BSA peptides) either in CEC or nano-LC. This work demonstrated high potentials for MOF-organic polymer monolith as stationary phase in miniaturized chromatography for the first time.
AB - In this study, metal organic framework (MOF)-organic polymer monoliths prepared via a 5-min microwave-assisted polymerization of ethylene dimethacrylate (EDMA), butyl methacrylate (BMA), and 2-acrylamido-2-methylpropane sulfonic acid (AMPS) with the addition of various weight percentages (30-60%) of porous MOF (MIL-101(Cr)) were developed as stationary phases for capillary electrochromatography (CEC) and nano-liquid chromatography (nano-LC). Powder X-ray diffraction (PXRD) patterns and nitrogen adsorption/desorption isotherms of these MOF-organic polymer monoliths showed the presence of the inherent characteristic peaks and the nano-sized pores of MIL-101(Cr), which confirmed an unaltered crystalline MIL-101(Cr) skeleton after synthesis; while energy dispersive spectrometer (EDS) and micro-FT-IR spectra suggested homogenous distribution of MIL-101(Cr) in the MIL-101(Cr)-poly(BMA-EDMA) monoliths. This hybrid MOF-polymer column demonstrated high permeability, with almost 800-fold increase compared to MOF packed column, and efficient separation of various analytes (xylene, chlorotoluene, cymene, aromatic acids, polycyclic aromatic hydrocarbons and trypsin digested BSA peptides) either in CEC or nano-LC. This work demonstrated high potentials for MOF-organic polymer monolith as stationary phase in miniaturized chromatography for the first time.
KW - Capillary electrochromatography
KW - Metal organic framework
KW - Nano-liquid chromatography
KW - Organic polymer monolith
UR - https://www.scopus.com/pages/publications/84877629204
UR - https://www.scopus.com/pages/publications/84877629204#tab=citedBy
U2 - 10.1016/j.aca.2013.03.071
DO - 10.1016/j.aca.2013.03.071
M3 - Article
AN - SCOPUS:84877629204
SN - 0003-2670
VL - 779
SP - 96
EP - 103
JO - Analytica Chimica Acta
JF - Analytica Chimica Acta
ER -