Mass production and dynamic imaging of fluorescent nanodiamonds

Yi Ren Chang, Hsu Yang Lee, Kowa Chen, Chun Chieh Chang, Dung Sheng Tsai, Chi Cheng Fu, Tsong Shin Lim, Yan Kai Tzeng, Chia Yi Fang, Chau Chung Han, Huan Cheng Chang, Wunshain Fann

研究成果: 雜誌貢獻文章同行評審

601 引文 斯高帕斯(Scopus)

摘要

Fluorescent nanodiamond is a new nanomaterial that possesses several useful properties, including good biocompatibility, excellent photostability and facile surface functionalizability. Moreover, when excited by a laser, defect centres within the nanodiamond emit photons that are capable of penetrating tissue, making them well suited for biological imaging applications. Here, we show that bright fluorescent nanodiamonds can be produced in large quantities by irradiating synthetic diamond nanocrystallites with helium ions. The fluorescence is sufficiently bright and stable to allow three-dimensional tracking of a single particle within the cell by means of either one- or two-photon-excited fluorescence microscopy. The excellent photophysical characteristics are maintained for particles as small as 25 nm, suggesting that fluorescent nanodiamond is an ideal probe for long-term tracking and imaging in vivo, with good temporal and spatial resolution.

原文英語
頁(從 - 到)284-288
頁數5
期刊Nature Nanotechnology
3
發行號5
DOIs
出版狀態已發佈 - 2008 五月

ASJC Scopus subject areas

  • Bioengineering
  • Atomic and Molecular Physics, and Optics
  • Biomedical Engineering
  • Materials Science(all)
  • Condensed Matter Physics
  • Electrical and Electronic Engineering

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