Magnetically enhanced high-specificity virus detection using bio-activated magnetic nanoparticles with antibodies as labeling markers

Shieh-Yueh Yang, W. C. Wang, C. B. Lan, C. H. Chen, J. J. Chieh, Herng-Er Horng*, Chin Yih Hong, Hong-Chang Yang, C. P. Tsai, C. Y. Yang, I. C. Cheng, W. C. Chung

*此作品的通信作者

研究成果: 雜誌貢獻期刊論文同行評審

29 引文 斯高帕斯(Scopus)

摘要

This study describes magnetically driven suppression of cross-reactions among molecules. First, the magnetic nanoparticles are coated with bio-probes and dispersed in liquid. The bio-probes can then bind with homologous or heterologous bio-targets. When alternating-current (ac) magnetic fields are applied, magnetic nanoparticles rotate driven by ac magnetic fields. Thus, the bio-targets bound on the surface of magnetic nanoparticles experience a centrifugal force. The centrifugal force can be manipulated by adjusting the angular frequency of the rotating magnetic nanoparticles. The angular frequency is determined by the applied ac magnetic field frequency. Since the binding force for good binding is much higher than that of poor binding, frequency manipulation is needed for the centrifugal force to be higher than the poor-binding force but lower than the good-binding force. Therefore, poor binding which contributes to cross reactions between molecules can be suppressed efficiently by control of the ac magnetic field frequency.

原文英語
頁(從 - 到)14-18
頁數5
期刊Journal of Virological Methods
164
發行號1-2
DOIs
出版狀態已發佈 - 2010 3月

ASJC Scopus subject areas

  • 病毒學

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