Magnetic susceptibility reduction method for magnetically labeled immunoassay

Chin Yih Hong; C. C. Wu; Y. C. Chiu; S. Y. Yang; H. E. Horng; H. C. Yang

doi:10.1063/1.2206557

Magnetic susceptibility reduction method for magnetically labeled immunoassay

Chin Yih Hong, C. C. Wu, Y. C. Chiu, S. Y. Yang, H. E. Horng^*, H. C. Yang

^*此作品的通信作者

研究成果: 雜誌貢獻 › 期刊論文 › 同行評審

146 引文斯高帕斯（Scopus）

摘要

In addition to synthesizing biofunctionalized magnetic nanopaticles for the purpose of magnetically labeling biomolecules, a system to measure the ac magnetic susceptibility of the labeled sample was developed. When a targeted biomolecule was mixed with magnetic fluid possessing biofunctionalized magnetic nanoparticles, portions of magnetic nanoparticles agglomerated to form clusters due to the association with the targeted biomolecule. Due to the formation of magnetic clusters, the measured ac magnetic susceptibility reduced. The relationship between the mixed-frequency ac magnetic susceptibility reduction and the amount of the detected biomolecule was established.

原文	英語
文章編號	212512
期刊	Applied Physics Letters
卷	88
發行號	21
DOIs	https://doi.org/10.1063/1.2206557
出版狀態	已發佈 - 2006 5月 21
對外發佈	是

ASJC Scopus subject areas

物理與天文學（雜項）

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10.1063/1.2206557

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title = "Magnetic susceptibility reduction method for magnetically labeled immunoassay",

abstract = "In addition to synthesizing biofunctionalized magnetic nanopaticles for the purpose of magnetically labeling biomolecules, a system to measure the ac magnetic susceptibility of the labeled sample was developed. When a targeted biomolecule was mixed with magnetic fluid possessing biofunctionalized magnetic nanoparticles, portions of magnetic nanoparticles agglomerated to form clusters due to the association with the targeted biomolecule. Due to the formation of magnetic clusters, the measured ac magnetic susceptibility reduced. The relationship between the mixed-frequency ac magnetic susceptibility reduction and the amount of the detected biomolecule was established.",

author = "Hong, {Chin Yih} and Wu, {C. C.} and Chiu, {Y. C.} and Yang, {S. Y.} and Horng, {H. E.} and Yang, {H. C.}",

note = "Funding Information: This work is supported by National Science Council of Taiwan under Grant Nos. 94-2120-M-003-002, 94-2112-M-003-018, 94-2112-M-003-004, and 94-2212-E-001, and by Ministry of Education, Taiwan, under Grant No. 91-N-FA01-2-4-2.",

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T1 - Magnetic susceptibility reduction method for magnetically labeled immunoassay

AU - Hong, Chin Yih

AU - Wu, C. C.

AU - Chiu, Y. C.

AU - Yang, S. Y.

AU - Horng, H. E.

AU - Yang, H. C.

N1 - Funding Information: This work is supported by National Science Council of Taiwan under Grant Nos. 94-2120-M-003-002, 94-2112-M-003-018, 94-2112-M-003-004, and 94-2212-E-001, and by Ministry of Education, Taiwan, under Grant No. 91-N-FA01-2-4-2.

PY - 2006/5/21

Y1 - 2006/5/21

N2 - In addition to synthesizing biofunctionalized magnetic nanopaticles for the purpose of magnetically labeling biomolecules, a system to measure the ac magnetic susceptibility of the labeled sample was developed. When a targeted biomolecule was mixed with magnetic fluid possessing biofunctionalized magnetic nanoparticles, portions of magnetic nanoparticles agglomerated to form clusters due to the association with the targeted biomolecule. Due to the formation of magnetic clusters, the measured ac magnetic susceptibility reduced. The relationship between the mixed-frequency ac magnetic susceptibility reduction and the amount of the detected biomolecule was established.

AB - In addition to synthesizing biofunctionalized magnetic nanopaticles for the purpose of magnetically labeling biomolecules, a system to measure the ac magnetic susceptibility of the labeled sample was developed. When a targeted biomolecule was mixed with magnetic fluid possessing biofunctionalized magnetic nanoparticles, portions of magnetic nanoparticles agglomerated to form clusters due to the association with the targeted biomolecule. Due to the formation of magnetic clusters, the measured ac magnetic susceptibility reduced. The relationship between the mixed-frequency ac magnetic susceptibility reduction and the amount of the detected biomolecule was established.

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Magnetic susceptibility reduction method for magnetically labeled immunoassay

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