@article{92e8578fb06644ddac5e21abac040b41,
title = "Magnetic Responsive Release of Nitric Oxide from an MOF-Derived Fe3O4@PLGA Microsphere for the Treatment of Bacteria-Infected Cutaneous Wound",
abstract = "Nitric oxide (NO) is an essential endogenous signaling molecule regulating multifaceted physiological functions in the (cardio)vascular, neuronal, and immune systems. Due to the short half-life and location-/concentration-dependent physiological function of NO, translational application of NO as a novel therapeutic approach, however, awaits a strategy for spatiotemporal control on the delivery of NO. Inspired by the magnetic hyperthermia and magneto-triggered drug release featured by Fe3O4 conjugates, in this study, we aim to develop a magnetic responsive NO-release material (MagNORM) featuring dual NO-release phases, namely, burst and steady release, for the selective activation of NO-related physiology and treatment of bacteria-infected cutaneous wound. After conjugation of NO-delivery [Fe(μ-S-thioglycerol)(NO)2]2 with a metal-organic framework (MOF)-derived porous Fe3O4@C, encapsulation of obtained conjugates within the thermo-responsive poly(lactic-co-glycolic acid) (PLGA) microsphere completes the assembly of MagNORM. Through continuous/pulsatile/no application of the alternating magnetic field (AMF) to MagNORM, moreover, burst/intermittent/slow release of NO from MagNORM demonstrates the AMF as an ON/OFF switch for temporal control on the delivery of NO. Under continuous application of the AMF, in particular, burst release of NO from MagNORM triggers an effective anti-bacterial activity against both Gram-positive Staphylococcus aureus (S. aureus) and Gram-negative Escherichia coli (E. coli). In addition to the magneto-triggered bactericidal effect of MagNORM against E. coli-infected cutaneous wound in mice, of importance, steady release of NO from MagNORM without the AMF promotes the subsequent collagen formation and wound healing in mice.",
keywords = "anti-bacterial, magnetic hyperthermia, magnetic responsive drug delivery, metal-organic framework, nitric oxide",
author = "Chung, {Chieh Wei} and Liao, {Bo Wen} and Huang, {Shu Wei} and Chiou, {Show Jen} and Chang, {Cheng Han} and Lin, {Sheng Ju} and Chen, {Bo Hao} and Liu, {Wei Ling} and Hu, {Shang Hsiu} and Chuang, {Yu Chun} and Lin, {Chia Her} and Hsu, {I. Jui} and Cheng, {Chao Min} and Huang, {Chieh Cheng} and Lu, {Tsai Te}",
note = "Funding Information: We gratefully acknowledge the financial support from the Ministry of Science and Technology, Taiwan (MOST 108-2113-M-007-011, MOST 109-2628-M-007-003-MY3, MOST 109-2622-M-007-003-CC2, MOST 110-2622-M-007-002) and National Tsing Hua University, Taiwan (grant no. 109Q2711E1 and 110Q2513E1). We thank National Synchrotron Radiation Research Center (Taiwan) for the support on SPXRD experiments; Ting-Yin Cheng (National Tsing Hua University) for the assistance on TGA experiments and data analysis; Young-Sheng Chen for the support on SQUID measurements and demagnetization of cMIL-88B; Tsai-Yun Li for the help on ICP-OES experiments; Dr. En-Hui Liu (Center For Nanotechnology, Materials Science, and Microsystems, NTHU) for technical support with SEM manipulation; Ching-Yen Lin (National Taiwan University) for TEM experiments; Chih-Chuan Huang (National Central University) for the assistance on HRTEM experiments; Siou-Yin Huang (National Chiao Tung University) for XPS measurements; Sheng-Fu Syu and Prof. Hsin-Cheng Chiu for the help on IR thermal camera; Prof. Shih-Yuan Lu for the assistance on the preparation of cMIL-88B; and Jia-Wei Liu for the valuable discussion. Publisher Copyright: {\textcopyright} 2022 American Chemical Society.",
year = "2022",
month = feb,
day = "9",
doi = "10.1021/acsami.1c20802",
language = "English",
volume = "14",
pages = "6343--6357",
journal = "ACS applied materials & interfaces",
issn = "1944-8244",
publisher = "American Chemical Society",
number = "5",
}