Magnetic nanoparticles for high-sensitivity detection on nucleic acids via superconducting-quantum-interference-device-based immunomagnetic reduction assay

Shieh-Yueh Yang, J. J. Chieh, W. C. Wang, C. Y. Yu, N. S. Hing, Herng-Er Horng, Chin Yih Hong, Hong-Chang Yang, C. F. Chang, H. Y. Lin

研究成果: 雜誌貢獻期刊論文同行評審

30 引文 斯高帕斯(Scopus)

摘要

In this work, we investigate the feasibility of detecting quantitatively DNA molecules utilizing the technology named after the immunomagnetic reduction (IMR) assay. Magnetic nanoparticles dispersed in a phosphate buffer saline solution were bio-functionalized with probing single-strand DNA. A superconducting quantum interference device (SQUID) ac magnetosusceptometer was employed to detect IMR signals related to the concentration of the target DNA. The results reveal that use of IMR assay had merits such as a high convenience level, e.g. wash-free processes and high sensitivity, down to pM, for DNA detection.

原文英語
頁(從 - 到)681-685
頁數5
期刊Journal of Magnetism and Magnetic Materials
323
發行號6
DOIs
出版狀態已發佈 - 2011 三月

ASJC Scopus subject areas

  • 電子、光磁材料
  • 凝聚態物理學

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