Magnetic assistance for suppressing cross-reactions between biomolecules in immunoassay

Chin Yih Hong, Shieh Yueh Yang, Herng Er Horng, Hong Chang Yang

    研究成果: 書貢獻/報告類型會議貢獻

    摘要

    A method involving the use of magnetic nanoparticles to suppress the cross-reactions in immunoassay is developed. Antibodies are coated onto magnetic nanoparticles. These antibodies bind with target and non-target molecules. Once an alternative-current magnetic field is applied, magnetic nanoparticles oscillate with the magnetic field. The target and non-target molecules attached onto magnetic nanoparticles via antibodies experience a centrifugal force, which is against the association between antibodies and target/non-target molecules. Theoretically, the centrifugal force is proportional to the square of the frequency of the applied magnetic field. Thus, the strength of the centrifugal force can be manipulated by changing the frequency of the applied magnetic field. By well controlling the frequency of applied magnetic field, the centrifugal force can be stronger than the binding between antibodies and non-target molecules, but still weaker than that of target molecules. Consequently, the binding between antibodies and non-target molecules is broken by the centrifugal force.

    原文英語
    主出版物標題ASME 2010 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference, IDETC/CIE2010
    頁面393-396
    頁數4
    4
    DOIs
    出版狀態已發佈 - 2010 十二月 1
    事件ASME 2010 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference, IDETC/CIE2010 - Montreal, QC, 加拿大
    持續時間: 2010 八月 152010 八月 18

    其他

    其他ASME 2010 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference, IDETC/CIE2010
    國家加拿大
    城市Montreal, QC
    期間10/8/1510/8/18

    ASJC Scopus subject areas

    • Modelling and Simulation
    • Mechanical Engineering
    • Computer Science Applications
    • Computer Graphics and Computer-Aided Design

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