LRRK2 A419V is not associated with Parkinson's disease in different Chinese populations

Yih Ru Wu, Louis C. Tan, Xiaoli Fu, Chiung Mei Chen, Wing Lok Au, Ling Chen, Yi Chun Chen, Kumar M. Prakash, Yifan Zheng, Guey Jen Lee-Chen, Yi Zhao, Jin Sheng Zeng, Eng King Tan, Zhong Pei

研究成果: 雜誌貢獻文章

6 引文 斯高帕斯(Scopus)

摘要

It has been suggested that a common LRRK2 polymorphic variant (A419V (rs34594498 C >T)) may be a risk factor among Asians (especially in Taiwan). In this study, we examined this variant in a larger and independent Taiwan cohort. We found the frequency of the variant (A419V) to be very rare in our Taiwan PD and controls (?0.6%). Further studies were conducted in two other Chinese populations (Singapore and China), comprising of a total of 3004 subjects including 1517 PD patients and 1487 control subjects. However, our multi-center Chinese study revealed that the frequency of the variant was rare (?0.4%) and was not associated with risk of PD, suggesting that the variant is not a major risk factor for PD among Chinese, at least in our study population.

原文英語
文章編號e36123
期刊PloS one
7
發行號7
DOIs
出版狀態已發佈 - 2012 七月 10

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

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