Long-term social isolation exacerbates the impairment of spatial working memory in APP/PS1 transgenic mice

Hei Jen Huang, Keng Chen Liang, Hsing Chieh Ke, Yen Yu Chang, Hsiu Mei Hsieh-Li

研究成果: 雜誌貢獻期刊論文同行評審

60 引文 斯高帕斯(Scopus)

摘要

The interaction between gene and environment is known to play a major role in the etiology of several neuropsychiatric disorders, including Alzheimer's disease (AD). The present study evaluated whether environmental manipulations such as social isolation may affect the genetic predisposition to accelerate the onset of AD-related symptoms in an adult APP/PS1 double mutant transgenic mouse model. Transgenic and wild-type male mice were housed either singly or in groups from the age of 3 months, and their behavior was compared at 7 months. Isolation had several effects on the APP/PS1 transgenic mice, including exacerbating the impairment of spatial working memory associated with increased Aβ42/Aβ40 ratio in the hippocampus; increased levels of MnSOD in the CA1-CA3 subregions of the hippocampus, basolateral part of the amygdala (BLA), and locus coeruleus (LC); and decreased numbers of cholinergic cells in the diagonal band of Broca (DB), noradrenergic neurons in LC, serotonergic neurons in the Raphe nucleus, and levels of NMDA 2B receptor (NR2B) in the hippocampus region. Our findings demonstrate the susceptibility of APP/PS1 transgenic adult male mice to environmental manipulation and show that social isolation has remarkable effects on the genetically determined AD-like symptoms.

原文英語
頁(從 - 到)150-160
頁數11
期刊Brain Research
1371
DOIs
出版狀態已發佈 - 2011 1月 31

ASJC Scopus subject areas

  • 神經科學 (全部)
  • 分子生物學
  • 神經病學(臨床)
  • 發展生物學

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