Lewis acid mediated diastereoselective allylation of camphorpyrazolidinone derived α-ketoamides

Shy Guey Wang, Huei Ru Tsai, Kwunmin Chen*

*此作品的通信作者

研究成果: 雜誌貢獻期刊論文同行評審

13 引文 斯高帕斯(Scopus)

摘要

Diastereoselective allylation of camphorpyrazolidinone derived α-ketoamides was examined using allyltributyltin in the presence of various Lewis acids. The corresponding optically enriched quarternary α-hydroxy carbonyls were obtained in reasonable to excellent material yields (51-95%) and with practical levels of stereoselectivity (up to >95% de) when a stoichiometric amount of Sn(OTf)2 was used. The stereochemical induction is discussed.

原文英語
頁(從 - 到)6183-6185
頁數3
期刊Tetrahedron Letters
45
發行號32
DOIs
出版狀態已發佈 - 2004 八月 2

ASJC Scopus subject areas

  • 生物化學
  • 藥物發現
  • 有機化學

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