Layered hydrogel of poly(γ-glutamic acid), sodium alginate, and chitosan: Fluorescence observation of structure and cytocompatibility

Yen Hsien Lee, Jung Jhih Chang, Wen Fu Lai, Ming Chien Yang, Chiang Ting Chien

研究成果: 雜誌貢獻文章同行評審

24 引文 斯高帕斯(Scopus)

摘要

In this study, a novel layered hydrogel composing of poly(γ-glutamic acid) (PGA), chitosan (CS), and alginate (AL) were prepared. Furthermore, PGA, CS, and AL were labeled with different fluorescent dyes. The bilayer structure of hydrogel was then revealed using these fluorescent labeled polymers. To mimic the stability of these hydrogels in physiological fluids, the dissolution of PGA and the release of Ca2+ from these hydrogels in normal saline were also monitored. The results showed that by adding CS to the hydrogel, the dissolution of PGA was decreased by 67%, and the release of Ca2+ was reduced by 40%. In addition, the hydrogel exhibited no cytotoxicity for L929 fibroblasts.

原文英語
頁(從 - 到)409-413
頁數5
期刊Colloids and Surfaces B: Biointerfaces
86
發行號2
DOIs
出版狀態已發佈 - 2011 九月 1

ASJC Scopus subject areas

  • Biotechnology
  • Surfaces and Interfaces
  • Physical and Theoretical Chemistry
  • Colloid and Surface Chemistry

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