The purpose of this study is to systematically investigate the effects of keyboard adaptations for children with cerebral palsy. Twelve children aged from 7 to 15 years old participated in this study. Keyboard adaptation strategies were developed based on the individualized assessments. A group comparison experimental design was selected to examine the effectiveness of keyboard adaptations. Speed and accuracy of typing Chinese were compared before and after keyboard adaptations. The results indicated that children with cerebral palsy did increase their typing performance after implementing keyboard adaptation strategies. The results of this study can provide health and educational profession a reference when serving children with physical disabilities.