I2-catalyzed Michael addition of indole and pyrrole to nitroolefins

Chunchi Lin, Jianming Hsu, M. N.V. Sastry, Hulin Fang, Zhijay Tu, Ju Tsung Liu, Yao Ching-Fa*

*此作品的通信作者

研究成果: 雜誌貢獻期刊論文同行評審

131 引文 斯高帕斯(Scopus)

摘要

An easy and efficient method to generate indolyl nitroalkane 5 and pyrrolyl nitroalkane 7 in high yields using β-nitrostyrene and indole/pyrrole at room temperature in the presence of catalytic amount of iodine is reported. The short reaction times and high yields of product are noteworthy. Molecular iodine promoted Michael addition is operationally simple and efficient method compared to the known Lewis acids or rare earth metal catalysts to generate different indolyl/pyrrolyl nitroalkanes in high yield.

原文英語
頁(從 - 到)11751-11757
頁數7
期刊Tetrahedron
61
發行號49
DOIs
出版狀態已發佈 - 2005 十二月 5

ASJC Scopus subject areas

  • 生物化學
  • 藥物發現
  • 有機化學

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