Islet amyloid: From fundamental biophysics to mechanisms of cytotoxicity

Ping Cao, Peter Marek, Harris Noor, Vadim Patsalo, Ling Hsien Tu, Hui Wang, Andisheh Abedini, Daniel P. Raleigh*


研究成果: 雜誌貢獻回顧評介論文同行評審

149 引文 斯高帕斯(Scopus)


Pancreatic islet amyloid is a characteristic feature of type 2 diabetes. The major protein component of islet amyloid is the polypeptide hormone known as islet amyloid polypeptide (IAPP, or amylin). IAPP is stored with insulin in the β-cell secretory granules and is released in response to the stimuli that lead to insulin secretion. IAPP is normally soluble and is natively unfolded in its monomeric state, but forms islet amyloid in type 2 diabetes. Islet amyloid is not the cause of type 2 diabetes, but it leads to β-cell dysfunction and cell death, and contributes to the failure of islet cell transplantation. The mechanism of IAPP amyloid formation is not understood and the mechanisms of cytotoxicity are not fully defined.

頁(從 - 到)1106-1118
期刊FEBS Letters
出版狀態已發佈 - 2013 4月 17

ASJC Scopus subject areas

  • 生物物理學
  • 結構生物學
  • 生物化學
  • 分子生物學
  • 遺傳學
  • 細胞生物學


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