Islet amyloid: From fundamental biophysics to mechanisms of cytotoxicity

Ping Cao, Peter Marek, Harris Noor, Vadim Patsalo, Ling Hsien Tu, Hui Wang, Andisheh Abedini, Daniel P. Raleigh

研究成果: 雜誌貢獻综述文章

113 引文 斯高帕斯(Scopus)

摘要

Pancreatic islet amyloid is a characteristic feature of type 2 diabetes. The major protein component of islet amyloid is the polypeptide hormone known as islet amyloid polypeptide (IAPP, or amylin). IAPP is stored with insulin in the β-cell secretory granules and is released in response to the stimuli that lead to insulin secretion. IAPP is normally soluble and is natively unfolded in its monomeric state, but forms islet amyloid in type 2 diabetes. Islet amyloid is not the cause of type 2 diabetes, but it leads to β-cell dysfunction and cell death, and contributes to the failure of islet cell transplantation. The mechanism of IAPP amyloid formation is not understood and the mechanisms of cytotoxicity are not fully defined.

原文英語
頁(從 - 到)1106-1118
頁數13
期刊FEBS Letters
587
發行號8
DOIs
出版狀態已發佈 - 2013 四月 17

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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    Cao, P., Marek, P., Noor, H., Patsalo, V., Tu, L. H., Wang, H., Abedini, A., & Raleigh, D. P. (2013). Islet amyloid: From fundamental biophysics to mechanisms of cytotoxicity. FEBS Letters, 587(8), 1106-1118. https://doi.org/10.1016/j.febslet.2013.01.046