Ion regulation in fish gills: Recent progress in the cellular and molecular mechanisms

Pung Pung Hwang, Tsung Han Lee, Li Yih Lin

研究成果: 雜誌貢獻回顧評介論文同行評審

313 引文 斯高帕斯(Scopus)

摘要

Fish encounter harsh ionic/osmotic gradients on their aquatic environments, and the mechanisms through which they maintain internal homeostasis are more challenging compared with those of terrestrial vertebrates. Gills are one of the major organs conducting the internal ionic and acid-base regulation, with specialized ionocytes as the major cells carrying out active transport of ions. Exploring the iono/osmoregulatory mechanisms in fish gills, extensive literature proposed several models, with many conflicting or unsolved issues. Recent studies emerged, shedding light on these issues with new opened windows on other aspects, on account of available advanced molecular/cellular physiological approaches and animal models. Respective types of ionocytes and ion transporters, and the relevant regulators for the mechanisms of NaCl secretion, Na+ uptake/acid secretion/NH4+ excretion, Ca2+ uptake, and Cl- uptake/base secretion, were identified and functionally characterized. These new ideas broadened our understanding of the molecular/cellular mechanisms behind the functional modification/regulation of fish gill ion transport during acute and long-term acclimation to environmental challenges. Moreover, a model for the systematic and local carbohydrate energy supply to gill ionocytes during these acclimation processes was also proposed. These provide powerful platforms to precisely study transport pathways and functional regulation of specific ions, transporters, and ionocytes; however, very few model species were established so far, whereas more efforts are needed in other species.

原文英語
頁(從 - 到)R28-R47
期刊American Journal of Physiology - Regulatory Integrative and Comparative Physiology
301
發行號1
DOIs
出版狀態已發佈 - 2011 七月 1

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

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