Iodine-catalyzed Michael addition of mercaptans to α,β- unsaturated ketones under solvent-free conditions

Cheng Ming Chu; Shijay Gao; M. N.V. Sastry; Ching Fa Yao

doi:10.1016/j.tetlet.2005.05.099

Iodine-catalyzed Michael addition of mercaptans to α,β- unsaturated ketones under solvent-free conditions

Cheng Ming Chu
, Shijay Gao
, M. N.V. Sastry
, Ching Fa Yao^*

^*此作品的通信作者

化學系

研究成果: 雜誌貢獻 › 期刊論文 › 同行評審

107 引文斯高帕斯（Scopus）

摘要

A simple and efficient method for the Michael reaction between various mercaptans and α,β-unsaturated ketones using a catalytic amount of iodine (5 mol %) to generate the 1,4-adduct has been reported. The significant features of the iodine catalyzed Michael addition are (a) operational simplicity, (b) inexpensive reagents, (c) high yields of products, (d) the use of relatively low or nontoxic reagents and (e) solvent-free conditions.

原文	英語
頁（從 - 到）	4971-4974
頁數	4
期刊	Tetrahedron Letters
卷	46
發行號	30
DOIs	https://doi.org/10.1016/j.tetlet.2005.05.099
出版狀態	已發佈 - 2005 7月 25

ASJC Scopus subject areas

生物化學
藥物發現
有機化學

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10.1016/j.tetlet.2005.05.099

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title = "Iodine-catalyzed Michael addition of mercaptans to α,β- unsaturated ketones under solvent-free conditions",

abstract = "A simple and efficient method for the Michael reaction between various mercaptans and α,β-unsaturated ketones using a catalytic amount of iodine (5 mol \%) to generate the 1,4-adduct has been reported. The significant features of the iodine catalyzed Michael addition are (a) operational simplicity, (b) inexpensive reagents, (c) high yields of products, (d) the use of relatively low or nontoxic reagents and (e) solvent-free conditions.",

keywords = "Catalytic amounts, Ecofriendly, Michael addition, Molecular iodine, Solvent free, Unsaturated ketones, Various thiols",

author = "Chu, \{Cheng Ming\} and Shijay Gao and Sastry, \{M. N.V.\} and Yao, \{Ching Fa\}",

note = "Funding Information: Financial support for this work by the National Science Council of the Republic of China and National Taiwan Normal University (ORD93-C) is gratefully acknowledged.",

year = "2005",

month = jul,

day = "25",

doi = "10.1016/j.tetlet.2005.05.099",

language = "English",

volume = "46",

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T1 - Iodine-catalyzed Michael addition of mercaptans to α,β- unsaturated ketones under solvent-free conditions

AU - Chu, Cheng Ming

AU - Gao, Shijay

AU - Sastry, M. N.V.

AU - Yao, Ching Fa

N1 - Funding Information: Financial support for this work by the National Science Council of the Republic of China and National Taiwan Normal University (ORD93-C) is gratefully acknowledged.

PY - 2005/7/25

Y1 - 2005/7/25

N2 - A simple and efficient method for the Michael reaction between various mercaptans and α,β-unsaturated ketones using a catalytic amount of iodine (5 mol %) to generate the 1,4-adduct has been reported. The significant features of the iodine catalyzed Michael addition are (a) operational simplicity, (b) inexpensive reagents, (c) high yields of products, (d) the use of relatively low or nontoxic reagents and (e) solvent-free conditions.

AB - A simple and efficient method for the Michael reaction between various mercaptans and α,β-unsaturated ketones using a catalytic amount of iodine (5 mol %) to generate the 1,4-adduct has been reported. The significant features of the iodine catalyzed Michael addition are (a) operational simplicity, (b) inexpensive reagents, (c) high yields of products, (d) the use of relatively low or nontoxic reagents and (e) solvent-free conditions.

KW - Catalytic amounts

KW - Ecofriendly

KW - Michael addition

KW - Molecular iodine

KW - Solvent free

KW - Unsaturated ketones

KW - Various thiols

UR - https://www.scopus.com/pages/publications/20544463219

UR - https://www.scopus.com/pages/publications/20544463219#tab=citedBy

U2 - 10.1016/j.tetlet.2005.05.099

DO - 10.1016/j.tetlet.2005.05.099

M3 - Article

AN - SCOPUS:20544463219

SN - 0040-4039

VL - 46

SP - 4971

EP - 4974

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 30

ER -

Iodine-catalyzed Michael addition of mercaptans to α,β- unsaturated ketones under solvent-free conditions

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