Iodine-catalyzed Michael addition of mercaptans to α,β- unsaturated ketones under solvent-free conditions

Cheng Ming Chu, Shijay Gao, M. N.V. Sastry, Ching Fa Yao*

*此作品的通信作者

研究成果: 雜誌貢獻期刊論文同行評審

106 引文 斯高帕斯(Scopus)

摘要

A simple and efficient method for the Michael reaction between various mercaptans and α,β-unsaturated ketones using a catalytic amount of iodine (5 mol %) to generate the 1,4-adduct has been reported. The significant features of the iodine catalyzed Michael addition are (a) operational simplicity, (b) inexpensive reagents, (c) high yields of products, (d) the use of relatively low or nontoxic reagents and (e) solvent-free conditions.

原文英語
頁(從 - 到)4971-4974
頁數4
期刊Tetrahedron Letters
46
發行號30
DOIs
出版狀態已發佈 - 2005 7月 25

ASJC Scopus subject areas

  • 生物化學
  • 藥物發現
  • 有機化學

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