Investigating the therapeutic effects of novel compounds targeting inflammatory IL-1β and IL-6 signaling pathways in spinocerebellar ataxia type 3

Pharmacology, Toxicology and Pharmaceutical Science

• Therapeutic Effect 100%
• Polyglutamine 100%
• Interleukin 1 100%
• Spinocerebellar Degeneration 100%
• Interleukin 6 100%
• Ataxin 3 75%
• Tafamidis 75%
• Anti-Inflammatory Drug 50%
• Lipopolysaccharide 50%
• Reactive Oxygen Metabolite 50%
• CD68 Antigen 50%
• Diseases 50%
• Interferon 50%
• Nervous System Inflammation 25%
• Pyrin 25%
• Tumor Necrosis Factor 25%
• Interleukin 1beta Converting Enzyme 25%
• Retinoic Acid 25%
• Janus Kinase 2 25%
• Coumarin Derivative 25%
• STAT1 Protein 25%
• Pharmacological Chaperone 25%
• STAT3 Protein 25%
• Mitogen Activated Protein Kinase 14 25%
• Lactate Dehydrogenase 25%
• Nitric Oxide 25%
• calcium activated,phospholipid dependent protein kinase 25%

Neuroscience

• Interleukin 6 100%
• Polyglutamine 100%
• Interleukin 1 100%
• Spinocerebellar Ataxia 100%
• Ataxin 3 75%
• Reactive Oxygen Species 50%
• Anti-Inflammatory 50%
• Lipopolysaccharide 50%
• Interferon 50%
• CD68 Antigen 50%
• Microglia 50%
• STAT1 50%
• Coumarin 25%
• Tretinoin 25%
• Protein Kinase C 25%
• STAT3 25%
• CAG Repeat 25%
• Lactate Dehydrogenase 25%
• Amino Terminal Sequence 25%
• Proto Oncogene 25%
• Janus Kinase 2 25%
• Neurite Outgrowth 25%
• Mitogen Activated Protein Kinase 14 25%
• Nitric Oxide 25%
• Chaperone 25%
• Caspase 1 25%
• Necrosis 25%
• Pyrin Domain 25%

INIS

• inflammation 100%
• interleukins 100%
• kinases 50%
• diseases 33%
• signals 33%
• proteins 33%
• oxygen 33%
• transcription 33%
• lipopolysaccharides 33%
• interferon 33%
• transducers 33%
• production 16%
• expansion 16%
• pathogenesis 16%
• mice 16%
• retinoic acid 16%
• aggregation 16%
• potentials 16%
• toxicity 16%
• nitric oxide 16%
• lactate dehydrogenase 16%
• coumarin 16%
• phosphorus 38 16%
• mitogens 16%
• tumor necrosis factor 16%
• oncogenes 16%
• antigens 16%