Interleukin-1α polymorphism has influence on late-onset sporadic Parkinson's disease in Taiwan

Y. R. Wu, C. M. Chen, J. C. Hwang, S. T. Chen, I. H. Feng, H. C. Hsu, C. N. Liu, Y. T. Liu, Y. Y. Lai, H. J. Huang, G. J. Lee-Chen*


研究成果: 雜誌貢獻期刊論文同行評審

13 引文 斯高帕斯(Scopus)


Inflammatory events may contribute to the pathogenesis of Parkinson's disease (PD) and interleukin 1 (IL-1) may exert both neurotoxic and neuroprotective effects. We conducted a case-control study in a cohort of 493 PD cases and 388 ethnically matched controls to investigate the association of IL-1α C-889T and IL-1β C-511T polymorphisms with the risk of PD. No significant difference in the genotype distribution of the analyzed polymorphisms was found between PD and controls. However, after stratification by age, individuals over 70 years of age carrying IL-1α-889 C/T genotype demonstrated a significant decrease in risk of developing PD (OR = 0.44; 95% CI = 0.22-0.88, p = 0.021) and the decrease is strengthened by IL-1β-511 T-carrying genotype (OR = 0.28; 95% CI = 0.11-0.71, p = 0.008). Our data suggest that IL-1α, acting synergistically with IL-1β, plays role in PD susceptibility among Taiwanese people older than 70 years of age.

頁(從 - 到)1173-1177
期刊Journal of Neural Transmission
出版狀態已發佈 - 2007 9月

ASJC Scopus subject areas

  • 神經內科
  • 神經病學(臨床)
  • 精神病學和心理健康
  • 生物精神病學


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