Insulin-like growth factor 1 triggers salt secretion machinery in fish under acute salinity stress

Jia Jiun Yan, Yi Chun Lee, Yi Ling Tsou, Yung Che Tseng, Pung Pung Hwang*

*此作品的通信作者

研究成果: 雜誌貢獻期刊論文同行評審

摘要

Timely adjustment of osmoregulation upon acute salinity stress is essential for the survival of euryhaline fish. This rapid response is thought to be tightly controlled by hormones; however, there are still questions unanswered. In this work, we tested the hypothesis that the endocrine hormone, insulin-like growth factor 1 (Igf1), a slow-acting hormone, is involved in the activation of salt secretion mechanisms in euryhaline medaka (Oryzias melastigma) during acclimation to acute salinity stress. In response to a 30-ppt seawater (SW) challenge, Na+/Cl− secretion was enhanced within 0.5 h, with concomitant organization of ionocyte multicellular complexes and without changes in expression of major transporters. Igf1 receptor inhibitors significantly impair the Na+/Cl− secretion and ionocyte multicellular complex responses without affecting transporter expression. Thus, Igf1 may activate salt secretion as part of the teleost response to acute salinity stress by exerting effects on transporter function and enhancing the formation of ionocyte multicellular complexes. These findings provide new insights into hormonal control of body fluid ionic/osmotic homeostasis during vertebrate evolution.

原文英語
頁(從 - 到)277-288
頁數12
期刊Journal of Endocrinology
246
發行號3
DOIs
出版狀態已發佈 - 2020 九月
對外發佈

ASJC Scopus subject areas

  • 內分泌學、糖尿病和代謝
  • 內分泌

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