Infection with Toxoplasma gondii increases the risk of psychiatric disorders in Taiwan: A nationwide population-based cohort study

Hsin An Lin, Wu Chien Chien, Kuo Yang Huang, Chi Hsiang Chung, Lih Chyang Chen, Hsin Chung Lin, Jong Long Guo

研究成果: 雜誌貢獻期刊論文同行評審

摘要

This study aimed to evaluate associations between toxoplasmosis and psychiatric disorders in Taiwan based on the National Health Insurance Research Database, Taiwan (1997-2013). Patients newly diagnosed with toxoplasmosis formed the case group (n = 259), and the control group included propensity-score matched patients without toxoplasmosis (n = 1036). The primary outcome was incidence of psychiatric disorders. Cox proportional hazards regression and stratified analyses were performed to examine risk of developing specific psychiatric disorders between patients with and without toxoplasmosis. Patients with toxoplasmosis had significantly higher incidence of psychiatric disorders than those without toxoplasmosis (P = 0.016). A significant difference was found in numbers of psychiatric disorders between the two groups during 14 years of follow-up (log-rank P < 0.001). Those with toxoplasmosis had significantly higher risk of bipolar disorder [adjusted hazard ratio (aHR = 3.60, 95% confidence interval (CI) = 2.07, 7.26), depression (aHR = 4.94, 95% CI = 2.15, 11.80) and anxiety (aHR = 5.36, 95% CI = 2.98, 25.88), but no significant between-group differences were found for schizophrenia and other psychiatric disorders. In conclusion, the present nationwide population-based analysis revealed that Toxoplasma gondii infection in Taiwan significantly increases the risk for developing bipolar disorder, depression and anxiety, but not for schizophrenia and other psychiatric disorders.

原文英語
頁(從 - 到)1577-1586
頁數10
期刊Parasitology
147
發行號13
DOIs
出版狀態已發佈 - 2020 十一月

ASJC Scopus subject areas

  • 寄生物學
  • 動物科學與動物學
  • 傳染性疾病

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