Increased risk of intracerebral hemorrhage among patients with chronic osteomyelitis

Chun Hung Tseng, Wei Shih Huang, Chih Hsin Muo, Yen Jung Chang, Fung Chang Sung

研究成果: 雜誌貢獻文章同行評審

6 引文 斯高帕斯(Scopus)


Object Inflammation may provoke cerebral arteriolar ectasia, inducing microaneurysm formation and further promoting intracerebral hemorrhage (ICH). Chronic osteomyelitis (COM) is an inflammatory disorder for which study of its role in ICH is lacking. This study explored whether COM increases the risk of ICH. Methods From Taiwan national insurance inpatient claims, 22,052 patients who were newly diagnosed with COM between 1997 and 2010 were identified; 88,207 age and sex frequency-matched subjects without COM were selected at random for comparison. Risks of ICH associated with COM and comorbidities, including hypertension, diabetes, hyperlipidemia, chronic kidney disease, and drug abuse, were assessed by the end of 2010. Results The incidence of ICH was 1.68 times higher in the COM cohort than in the comparison cohort, with an adjusted hazard ratio (HR) of 1.50 (95% CI 1.29-1.74) estimated in the multivariable Cox model. Age-specific analysis showed that the HR of ICH for COM patients decreased with age, with an adjusted HR of 3.28 (95% CI 1.88-5.75) in the < 40-year age group, which declined to 1.11 (95% CI 0.88-1.40) in the elderly. The incidence of ICH increased with the severity of COM; for those with severe COM the adjusted HR was 4.42 (95% CI 3.31-5.89). For subjects without comorbidities, the incidence of ICH was 1.20-fold (95% CI 1.00-1.45) higher in the COM cohort than in the comparison cohort. Conclusions This study suggests for the first time that COM is an inflammatory factor associated with increased risk of ICH, especially in younger patients.

頁(從 - 到)1528-1533
期刊Journal of Neurosurgery
出版狀態已發佈 - 2015 十二月

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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