Increased expression of osteopontin gene in atypical teratoid/rhabdoid tumor of the central nervous system

Chung Lan Kao, Shih Hwa Chiou, Yann Jang Chen, Sher Singh, Han Tso Lin, Ren Shyan Liu, Chih Wen Lo, Chi Chang Yang, Chin Wen Chi, Chen Hsen Lee, Tai Tong Wong

研究成果: 雜誌貢獻文章

27 引文 斯高帕斯(Scopus)

摘要

The atypical teratoid/rhabdoid tumor, primary to the central nervous system, is a highly malignant and aggressive neoplasm of infancy and childhood. Although having distinct biological features and clinical outcomes, it is frequently misdiagnosed as primitive neuroectodermal tumor/medulloblastoma. To further distinguish the underlying pathogenesis and to identify biological markers for clinical use, an atypical teratoid/rhabdoid tumor-derived cell line was established and its gene expression pattern analyzed in comparison to the human astrocyte SVG12 cell line and the human DAOY medulloblastoma cell line using a complementary DNA microarray method. The osteopontin gene was found specifically upregulated in atypical teratoid/rhabdoid tumor cells. This specificity was confirmed by immunohistochemistry in pathological sections of tissues from atypical teratoid/rhabdoid tumor patients. Even though the role of osteopontin in the cytopathogenesis of atypical teratoid/rhabdoid tumor still needs to be determined, our data support that overexpressed osteopontin is a potential diagnostic marker for atypical teratoid/rhabdoid tumor.

原文英語
頁(從 - 到)769-778
頁數10
期刊Modern Pathology
18
發行號6
DOIs
出版狀態已發佈 - 2005 六月 1

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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    Kao, C. L., Chiou, S. H., Chen, Y. J., Singh, S., Lin, H. T., Liu, R. S., Lo, C. W., Yang, C. C., Chi, C. W., Lee, C. H., & Wong, T. T. (2005). Increased expression of osteopontin gene in atypical teratoid/rhabdoid tumor of the central nervous system. Modern Pathology, 18(6), 769-778. https://doi.org/10.1038/modpathol.3800270