In-vivo and fast examination of iron concentration of magnetic nano-particles in an animal torso via scanning SQUID biosusceptometry

W. K. Tseng, Jen-Je Chieh, Shieh-Yueh Yang, Herng-Er Horng, C. Y. Hong, Hong-Chang Yang, C. C. Wu

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    5 引文 斯高帕斯(Scopus)

    摘要

    To determine the iron concentration of administrated magnetic nano-particles in animals is essential for evaluation of arrival efficiency in target regions in biomagnetism studies. In this work, a high T c superconucting quantum interference devices (SQUID) biosusceptometry with a scanning coil set is developed. The measurement principal is based on the AC susceptibility of magnetic nano-particles, and the low noise of 8 pT/√Hz at 400 Hz is characterized in unshielded environment. The dextran-coated magnetic nano-particle of 50 nm in diameter is administrated intravenously into Wistar male rats to demonstrate the in-vivo and fast examination feasibility of this instrument. The in-vivo results of heart region and liver region explained the reasonable biological phenomenon of magnetic nano-particles in animals. Good correlation of concentration-time curve between the induction-coupled-plasma (ICP) and in-vivo examination by AC susceptibility measurement in rat liver region until 4 hours after injection of magnetic naoparticle validates the in-vivo measurement of iron concentration. After 4 hrs post magnetic nanoparticle injection, the phagocyted magnetic nano-particles in liver tissue shows antiferromagnetism properties and explain the difference between the low in-vivo intensity by AC susceptibility measurement and high intensity by ICP.

    原文英語
    文章編號5721748
    頁(從 - 到)2250-2253
    頁數4
    期刊IEEE Transactions on Applied Superconductivity
    21
    發行號3 PART 2
    DOIs
    出版狀態已發佈 - 2011 六月 1

    ASJC Scopus subject areas

    • Electronic, Optical and Magnetic Materials
    • Condensed Matter Physics
    • Electrical and Electronic Engineering

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