In-vitro diagnosis of colon cancer using bio-functionalized magnetic nanoparticles

Chin Yih Hong; Shieh Yueh Yang; K. W. Huang; Herng Er Horng; Hong Chang Yang

doi:10.1115/DETC2011-47178

In-vitro diagnosis of colon cancer using bio-functionalized magnetic nanoparticles

Chin Yih Hong^*
, Shieh Yueh Yang
, K. W. Huang
, Herng Er Horng
, Hong Chang Yang

^*此作品的通信作者

光電工程研究所暨學士學位學程

研究成果: 書貢獻/報告類型 › 會議論文篇章

摘要

The popular bio-marker for colon cancer is carcinoembryonic antigen (CEA). By conjugating anti-CEA onto magnetic nanoparticles, CEA can be specially labeled and detected by measuring magnetic signals via immunomagnetic reduction (IMR). The low detection limit and detection range of IMR on CEA are investigated. The results are compared with those by using the existing assay, such as enzyme-linked immunosorbent assay (ELISA). It is evidenced that IMR has sensitivity much higher than that of ELISA. The low detection limit is below the normal level of CEA concentration of clinic practice and is suitable for early-stage in-vitro diagnosis for colon cancer. Furthermore, the dynamic range of detection for the CEA concentration using IMR extends well above the threshold of high risk level of colorectal carcinoma in current diagnosing practice. Therefore, IMR is also suitable in other stages diagnosis for colon cancer development.

原文	英語
主出版物標題	ASME 2011 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference, IDETC/CIE 2011
頁面	11-15
頁數	5
DOIs	https://doi.org/10.1115/DETC2011-47178
出版狀態	已發佈 - 2011
事件	ASME 2011 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference, IDETC/CIE 2011 - Washington, DC, 美国持續時間: 2011 8月 28 → 2011 8月 31

出版系列

名字	Proceedings of the ASME Design Engineering Technical Conference
卷	7

會議

會議	ASME 2011 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference, IDETC/CIE 2011
國家/地區	美国
城市	Washington, DC
期間	2011/08/28 → 2011/08/31

UN SDG

此研究成果有助於以下永續發展目標

SDG 3 健康與福祉

ASJC Scopus subject areas

建模與模擬
機械工業
電腦科學應用
電腦繪圖與電腦輔助設計

存取文件

10.1115/DETC2011-47178

其它文件與鏈接

引用此

Hong, C. Y., Yang, S. Y., Huang, K. W., Horng, H. E., & Yang, H. C. (2011). In-vitro diagnosis of colon cancer using bio-functionalized magnetic nanoparticles. 於 ASME 2011 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference, IDETC/CIE 2011 (頁 11-15). (Proceedings of the ASME Design Engineering Technical Conference; 卷 7). https://doi.org/10.1115/DETC2011-47178

In-vitro diagnosis of colon cancer using bio-functionalized magnetic nanoparticles. / Hong, Chin Yih; Yang, Shieh Yueh; Huang, K. W. 等.
ASME 2011 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference, IDETC/CIE 2011. 2011. p. 11-15 (Proceedings of the ASME Design Engineering Technical Conference; 卷 7).

研究成果: 書貢獻/報告類型 › 會議論文篇章

Hong, CY, Yang, SY, Huang, KW, Horng, HE & Yang, HC 2011, In-vitro diagnosis of colon cancer using bio-functionalized magnetic nanoparticles. 於 ASME 2011 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference, IDETC/CIE 2011. Proceedings of the ASME Design Engineering Technical Conference, 卷 7, 頁 11-15, ASME 2011 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference, IDETC/CIE 2011, Washington, DC, 美国, 2011/08/28. https://doi.org/10.1115/DETC2011-47178

Hong CY, Yang SY, Huang KW, Horng HE, Yang HC. In-vitro diagnosis of colon cancer using bio-functionalized magnetic nanoparticles. 於 ASME 2011 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference, IDETC/CIE 2011. 2011. p. 11-15. (Proceedings of the ASME Design Engineering Technical Conference). doi: 10.1115/DETC2011-47178

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title = "In-vitro diagnosis of colon cancer using bio-functionalized magnetic nanoparticles",

abstract = "The popular bio-marker for colon cancer is carcinoembryonic antigen (CEA). By conjugating anti-CEA onto magnetic nanoparticles, CEA can be specially labeled and detected by measuring magnetic signals via immunomagnetic reduction (IMR). The low detection limit and detection range of IMR on CEA are investigated. The results are compared with those by using the existing assay, such as enzyme-linked immunosorbent assay (ELISA). It is evidenced that IMR has sensitivity much higher than that of ELISA. The low detection limit is below the normal level of CEA concentration of clinic practice and is suitable for early-stage in-vitro diagnosis for colon cancer. Furthermore, the dynamic range of detection for the CEA concentration using IMR extends well above the threshold of high risk level of colorectal carcinoma in current diagnosing practice. Therefore, IMR is also suitable in other stages diagnosis for colon cancer development.",

keywords = "Carcinoembryonic antigen, Colorectal carcinoma, Enzyme-linked immunosorbent assay, Immunomagnetic reduction",

author = "Hong, \{Chin Yih\} and Yang, \{Shieh Yueh\} and Huang, \{K. W.\} and Horng, \{Herng Er\} and Yang, \{Hong Chang\}",

year = "2011",

doi = "10.1115/DETC2011-47178",

language = "English",

isbn = "9780791854846",

series = "Proceedings of the ASME Design Engineering Technical Conference",

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booktitle = "ASME 2011 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference, IDETC/CIE 2011",

note = "ASME 2011 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference, IDETC/CIE 2011 ; Conference date: 28-08-2011 Through 31-08-2011",

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T1 - In-vitro diagnosis of colon cancer using bio-functionalized magnetic nanoparticles

AU - Hong, Chin Yih

AU - Yang, Shieh Yueh

AU - Huang, K. W.

AU - Horng, Herng Er

AU - Yang, Hong Chang

PY - 2011

Y1 - 2011

N2 - The popular bio-marker for colon cancer is carcinoembryonic antigen (CEA). By conjugating anti-CEA onto magnetic nanoparticles, CEA can be specially labeled and detected by measuring magnetic signals via immunomagnetic reduction (IMR). The low detection limit and detection range of IMR on CEA are investigated. The results are compared with those by using the existing assay, such as enzyme-linked immunosorbent assay (ELISA). It is evidenced that IMR has sensitivity much higher than that of ELISA. The low detection limit is below the normal level of CEA concentration of clinic practice and is suitable for early-stage in-vitro diagnosis for colon cancer. Furthermore, the dynamic range of detection for the CEA concentration using IMR extends well above the threshold of high risk level of colorectal carcinoma in current diagnosing practice. Therefore, IMR is also suitable in other stages diagnosis for colon cancer development.

AB - The popular bio-marker for colon cancer is carcinoembryonic antigen (CEA). By conjugating anti-CEA onto magnetic nanoparticles, CEA can be specially labeled and detected by measuring magnetic signals via immunomagnetic reduction (IMR). The low detection limit and detection range of IMR on CEA are investigated. The results are compared with those by using the existing assay, such as enzyme-linked immunosorbent assay (ELISA). It is evidenced that IMR has sensitivity much higher than that of ELISA. The low detection limit is below the normal level of CEA concentration of clinic practice and is suitable for early-stage in-vitro diagnosis for colon cancer. Furthermore, the dynamic range of detection for the CEA concentration using IMR extends well above the threshold of high risk level of colorectal carcinoma in current diagnosing practice. Therefore, IMR is also suitable in other stages diagnosis for colon cancer development.

KW - Carcinoembryonic antigen

KW - Colorectal carcinoma

KW - Enzyme-linked immunosorbent assay

KW - Immunomagnetic reduction

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UR - https://www.scopus.com/pages/publications/84863591990#tab=citedBy

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M3 - Conference contribution

AN - SCOPUS:84863591990

SN - 9780791854846

T3 - Proceedings of the ASME Design Engineering Technical Conference

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BT - ASME 2011 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference, IDETC/CIE 2011

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Y2 - 28 August 2011 through 31 August 2011

ER -

In-vitro diagnosis of colon cancer using bio-functionalized magnetic nanoparticles

摘要

出版系列

會議

UN SDG

ASJC Scopus subject areas

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