In-vitro diagnosis of colon cancer using bio-functionalized magnetic nanoparticles

Chin Yih Hong*, Shieh Yueh Yang, K. W. Huang, Herng Er Horng, Hong Chang Yang

*此作品的通信作者

研究成果: 書貢獻/報告類型會議論文篇章

摘要

The popular bio-marker for colon cancer is carcinoembryonic antigen (CEA). By conjugating anti-CEA onto magnetic nanoparticles, CEA can be specially labeled and detected by measuring magnetic signals via immunomagnetic reduction (IMR). The low detection limit and detection range of IMR on CEA are investigated. The results are compared with those by using the existing assay, such as enzyme-linked immunosorbent assay (ELISA). It is evidenced that IMR has sensitivity much higher than that of ELISA. The low detection limit is below the normal level of CEA concentration of clinic practice and is suitable for early-stage in-vitro diagnosis for colon cancer. Furthermore, the dynamic range of detection for the CEA concentration using IMR extends well above the threshold of high risk level of colorectal carcinoma in current diagnosing practice. Therefore, IMR is also suitable in other stages diagnosis for colon cancer development.

原文英語
主出版物標題ASME 2011 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference, IDETC/CIE 2011
頁面11-15
頁數5
DOIs
出版狀態已發佈 - 2011
事件ASME 2011 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference, IDETC/CIE 2011 - Washington, DC, 美国
持續時間: 2011 八月 282011 八月 31

出版系列

名字Proceedings of the ASME Design Engineering Technical Conference
7

會議

會議ASME 2011 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference, IDETC/CIE 2011
國家/地區美国
城市Washington, DC
期間2011/08/282011/08/31

ASJC Scopus subject areas

  • 建模與模擬
  • 機械工業
  • 電腦科學應用
  • 電腦繪圖與電腦輔助設計

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