@article{40c283e2689f469c920ce1551bc3d7bb,
title = "Immunomagnetic Reduction Detects Plasma Aβ1–42 Levels as a Potential Dominant Indicator Predicting Cognitive Decline",
abstract = "Although the concentrations of Alzheimer{\textquoteright}s disease (AD) biomarkers Aβ1–40, Aβ1–42 and tau protein are very low in human plasma, ultrasensitive assays such as immunomagnetic reduction (IMR) are able to precisely quantify them. Review articles have described the detailed working mechanism of IMR and revealed the feasibility of detecting early-stage AD by assaying these plasma biomarkers with IMR. In this review, we aimed to compare the significance of these plasma biomarkers in predicting cognitive decline in patients with Down syndrome, stroke, or amnestic mild cognitive impairment based on findings in the literature. We found that plasma Aβ1–42 might play the predominant role in predicting cognitive decline in these patients.",
keywords = "Cognitive decline, Down syndrome, Immunomagnetic reduction, Plasma biomarkers, Stroke",
author = "Yang, {Shieh Yueh} and Liu, {Huei Chun} and Chen, {Wen Ping}",
note = "Funding Information: The study, the Rapid Service Fee, and/or the Open Access fee were funded by MagQu Co., Ltd. All named authors take responsibility for the integrity of the work as a whole and have given their approval for this version to be published. Shieh-Yueh Yang and Huei-Chun Liu are employees of MagQu Co., Ltd. Wen-Ping Chen is an employee of MagQu LLC. Shieh-Yueh Yang is a shareholder of MagQu Co., Ltd. This is a review article that is based on reported studies and does not contain any new studies with human participants or animals performed by any of the authors. Data sharing is not applicable to this article, as no datasets were generated or analyzed during the current study. Publisher Copyright: {\textcopyright} 2020, The Author(s).",
year = "2020",
month = dec,
day = "1",
doi = "10.1007/s40120-020-00215-2",
language = "English",
volume = "9",
pages = "435--442",
journal = "Neurology and Therapy",
issn = "2193-8253",
publisher = "Springer Healthcare",
number = "2",
}
