Immunomagnetic reduction assay using high-Tc superconducting-quantum-interference-device-based magnetosusceptometry

J. J. Chieh, Shieh Yueh Yang, Herng Er Horng, C. Y. Yu, C. L. Lee, H. L. Wu, Chin Yih Hong, Hong Chang Yang

    研究成果: 雜誌貢獻期刊論文同行評審

    26 引文 斯高帕斯(Scopus)

    摘要

    Via immunomagnetic reduction assay, biomolecules can be quantitatively detected with aid of biofunctionalized magnetic nanoparticles, which are used as labeling markers for specific biomolecules. To achieve ultra-high sensitivity in detecting biomolecules, superconducting quantum interference device (SQUID) is a promising candidate to act as a sensor to the magnetic signal related to the concentration of detected biomolecules. In the past, we developed a single channel SQUID-based magnetosusceptometry. In order to increase the detection through-put, multichannel SQUID-based magnetosusceptometry is developed. In this work, the design and working principle of four-channel SQUID-based magnetosusceptometry are introduced. Using utilizing scanning technology, four samples can be simultaneously logged into the SQUID-based magnetosusceptometry. Notably, only single SQUID magnetometer is used in the magnetosusceptometry. The precision and sensitivity in detecting biomolecules using the four-channel SQUID-based magnetosusceptometry are investigated.

    原文英語
    文章編號074903
    期刊Journal of Applied Physics
    107
    發行號7
    DOIs
    出版狀態已發佈 - 2010 四月 1

    ASJC Scopus subject areas

    • Physics and Astronomy(all)

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