Hormonal responses to a 160-km race across frozen Alaska

W. J. Kraemer*, M. S. Fragala, G. Watson, J. S. Volek, M. R. Rubin, D. N. French, C. M. Maresh, J. L. Vingren, D. L. Hatfield, B. A. Spiering, J. Yu-Ho, S. L. Hughes, H. S. Case, K. J. Stuempfle, D. R. Lehmann, S. Bailey, D. S. Evans

*此作品的通信作者

研究成果: 雜誌貢獻期刊論文同行評審

44 引文 斯高帕斯(Scopus)

摘要

Background: Severe physical and environmental stress seems to have a suppressive effect on the hypothalamic-pituitary-gonadal (HPG) axis in men. Examining hormonal responses to an extreme 160-km competition across frozen Alaska provides a unique opportunity to study this intense stress. Objective: To examine hormonal responses to an ultraendurance race. Methods: Blood samples were obtained from 16 men before and after racing and analyzed for testosterone, interleukin-6 (IL-6), growth hormone (GH) and cortisol. Six subjects (mean (SD) age 42 (7) years; body mass 78.9 (7.1) kg; height 1.78 (0.05) m raced by bicycle (cyclists) and 10 subjects (age 35 (9) years; body mass 77.9 (10.6) kg; height, 1.82 (0.05) m) raced by foot (runners). Mean (SD) finish times were 21.83 (6.27) and 33.98 (6.12) h, respectively. Results: In cyclists there were significant (p ≤ 0.05) mean (SD) pre-race to post-race increases in cortisol (254.83 (135.26) to 535.99 (232.22) nmol/l), GH (0.12 (0.23) to 3.21 (3.33) μg/ml) and IL-6 (2.36 (0.42) to 10.15 (3.28) pg/ml), and a significant decrease in testosterone (13.81 (3.19) to 5.59 (3.74) nmol/l). Similarly, in runners there were significant pre-race to post-race increases in cortisol (142.09 (50.74) to 452.21 (163.40) ng/ml), GH (0.12 (0.23) to 3.21 (3.33) μg/ml) and IL-6 (2.42 (0.68) to 12.25 (1.78) pg/ml), and a significant decrease in testosterone (12.32 (4.47) to 6.96 (3.19) nmol/l). There were no significant differences in the hormonal levels between cyclists and runners (p>0.05). Conclusions: These data suggest a suppression of the hypopituitary-gonadal axis potentially mediated by amplification of adrenal stress responses to such an ultra-endurance race in environmentally stressful conditions.

原文英語
頁(從 - 到)116-120
頁數5
期刊British Journal of Sports Medicine
42
發行號2
DOIs
出版狀態已發佈 - 2008 2月
對外發佈

ASJC Scopus subject areas

  • 物理治療、運動療法和康復
  • 骨科和運動醫學

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