摘要
This study presents an ultra-sensitive carboxyl-functionalized graphene oxide (GO-COOH)-based surface plasmon resonance (SPR) immunosensor using Carbohydrate antigen (CA) 199 (CA199) biomarker to detect pancreatic cancer. A study of the effect of carboxyl-GO-based biocompatible composites with protein on sensing adhesion and diagnostic engineering is an useful technique. The optical and sensing properties of carboxyl-GO sheets improved sensitivity and affinity for molecular detection of biomarker. In the experiment, the SPR biosensor with carboxyl modified graphene oxide as substrate was tested to detect the immune response of CA 199. The literature indicates that 79% of pancreatic cancer patients have carbohydrate antigen 19-9 content above 37 unit/ml. The experimental results show that the lowest antigen detection limit of surface plasmon resonance biochip with carboxyl modified graphene oxide as the substrate can reach 10 unit/ml.
| 原文 | 英語 |
|---|---|
| 主出版物標題 | Optical Sensors 2019 |
| 編輯 | Francesco Baldini, Jiri Homola, Robert A. Lieberman |
| 發行者 | SPIE |
| ISBN（電子） | 9781510627222 |
| DOIs | |
| 出版狀態 | 已發佈 - 2019 |
| 事件 | Optical Sensors 2019 - Prague, 捷克共和国 持續時間: 2019 4月 1 → 2019 4月 4 |
出版系列
| 名字 | Proceedings of SPIE - The International Society for Optical Engineering |
|---|---|
| 卷 | 11028 |
| ISSN（列印） | 0277-786X |
| ISSN（電子） | 1996-756X |
會議
| 會議 | Optical Sensors 2019 |
|---|---|
| 國家/地區 | 捷克共和国 |
| 城市 | Prague |
| 期間 | 2019/04/01 → 2019/04/04 |
ASJC Scopus subject areas
- 電子、光磁材料
- 凝聚態物理學
- 電腦科學應用
- 應用數學
- 電氣與電子工程
UN SDG
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