Highly sensitive carboxyl-graphene oxide-based SPR immunosensor for the detection of CA19-9 biomarker

Nan Fu Chiu, Shi Yuan Fan

研究成果: 書貢獻/報告類型會議貢獻

摘要

This study presents an ultra-sensitive carboxyl-functionalized graphene oxide (GO-COOH)-based surface plasmon resonance (SPR) immunosensor using Carbohydrate antigen (CA) 199 (CA199) biomarker to detect pancreatic cancer. A study of the effect of carboxyl-GO-based biocompatible composites with protein on sensing adhesion and diagnostic engineering is an useful technique. The optical and sensing properties of carboxyl-GO sheets improved sensitivity and affinity for molecular detection of biomarker. In the experiment, the SPR biosensor with carboxyl modified graphene oxide as substrate was tested to detect the immune response of CA 199. The literature indicates that 79% of pancreatic cancer patients have carbohydrate antigen 19-9 content above 37 unit/ml. The experimental results show that the lowest antigen detection limit of surface plasmon resonance biochip with carboxyl modified graphene oxide as the substrate can reach 10 unit/ml.

原文英語
主出版物標題Optical Sensors 2019
編輯Francesco Baldini, Jiri Homola, Robert A. Lieberman
發行者SPIE
ISBN(電子)9781510627222
DOIs
出版狀態已發佈 - 2019
事件Optical Sensors 2019 - Prague, 捷克共和国
持續時間: 2019 四月 12019 四月 4

出版系列

名字Proceedings of SPIE - The International Society for Optical Engineering
11028
ISSN(列印)0277-786X
ISSN(電子)1996-756X

會議

會議Optical Sensors 2019
國家捷克共和国
城市Prague
期間2019/04/012019/04/04

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

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