Highly functionalized benzene syntheses by directed mono or multiple magnesiations with TMPMgCl·LiCl

Wenwei Lin; Oliver Baron; Paul Knochel

doi:10.1021/ol0625536

Highly functionalized benzene syntheses by directed mono or multiple magnesiations with TMPMgCl·LiCl

Wenwei Lin, Oliver Baron, Paul Knochel^*

^*此作品的通信作者

研究成果: 雜誌貢獻 › 期刊論文 › 同行評審

141 引文斯高帕斯（Scopus）

摘要

The direct magnesiation of highly functionalized aromatics bearing an ester, a nitrile, or a ketone can be readily performed by using an OBoc as a directing group and TMPMgCl·LiCl as a base. It allows, for example, the preparation of a meta-magnesiated benzophenone in >95%. After quenching, highly functionalized and substituted benzenes are obtained.

原文	英語
頁（從 - 到）	5673-5676
頁數	4
期刊	Organic Letters
卷	8
發行號	24
DOIs	https://doi.org/10.1021/ol0625536
出版狀態	已發佈 - 2006 11月 23
對外發佈	是

ASJC Scopus subject areas

生物化學
物理與理論化學
有機化學

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10.1021/ol0625536

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abstract = "The direct magnesiation of highly functionalized aromatics bearing an ester, a nitrile, or a ketone can be readily performed by using an OBoc as a directing group and TMPMgCl·LiCl as a base. It allows, for example, the preparation of a meta-magnesiated benzophenone in >95%. After quenching, highly functionalized and substituted benzenes are obtained.",

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AB - The direct magnesiation of highly functionalized aromatics bearing an ester, a nitrile, or a ketone can be readily performed by using an OBoc as a directing group and TMPMgCl·LiCl as a base. It allows, for example, the preparation of a meta-magnesiated benzophenone in >95%. After quenching, highly functionalized and substituted benzenes are obtained.

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Highly functionalized benzene syntheses by directed mono or multiple magnesiations with TMPMgCl·LiCl

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