Highly enantioselective synthesis of (E)-allylic alcohols

Hsyueh-Liang Wu, Ping Yu Wu, Biing Jiun Uang

研究成果: 雜誌貢獻文章同行評審

28 引文 斯高帕斯(Scopus)

摘要

(Chemical Equation Presented) The asymmetric addition of alkenylzincs to aromatic and a-branched aliphatic aldehydes catalyzed by 1 generated the corresponding (E)-allylic alcohols with >95% ee and good to excellent chemical yields, especially >99.5% ee was observed in the case of 4-CF 3-benzaldehyde. Notably, 1 is an effective ligand to catalyze the addition of disubstituted (R2 = R3 = ethyl) and bulky substituted (R2 - H, R3 = tert-butyl) alkenylzincs to benzaldehyde, affording the corresponding allylic alcohols both with 96% ee.

原文英語
頁(從 - 到)5935-5937
頁數3
期刊Journal of Organic Chemistry
72
發行號15
DOIs
出版狀態已發佈 - 2007 七月 20

ASJC Scopus subject areas

  • Organic Chemistry

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