Highly enantioselective conjugate addition of ketones to alkylidene malonates catalyzed by a pyrrolidinyl-camphor-derived organocatalyst

Dhananjay R. Magar, Chihliang Chang, Ying Fang Ting, Kwunmin Chen*

*此作品的通信作者

研究成果: 雜誌貢獻期刊論文同行評審

31 引文 斯高帕斯(Scopus)

摘要

Pyrrolidinyl-camphor derivatives have been proven to be efficient organocatalysts for enantioselective conjugate addition of ketones to alkylidene malonates, affording high chemical yields (up to 95 %) of the corresponding products with high to excellent levels of diastereoselectivity (up to >99:1 dr) and enantioselectivity (up to 96%ee) under solvent-free reaction conditions at ambient temperature.

原文英語
頁(從 - 到)2062-2066
頁數5
期刊European Journal of Organic Chemistry
發行號11
DOIs
出版狀態已發佈 - 2010 四月

ASJC Scopus subject areas

  • 物理與理論化學
  • 有機化學

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