Highly enantioselective conjugate addition of ketones to alkylidene malonates catalyzed by a pyrrolidinyl-camphor-derived organocatalyst

Dhananjay R. Magar; Chihliang Chang; Ying Fang Ting; Kwunmin Chen

doi:10.1002/ejoc.201000072

Highly enantioselective conjugate addition of ketones to alkylidene malonates catalyzed by a pyrrolidinyl-camphor-derived organocatalyst

Dhananjay R. Magar, Chihliang Chang, Ying Fang Ting, Kwunmin Chen^*

^*此作品的通信作者

化學系

研究成果: 雜誌貢獻 › 期刊論文 › 同行評審

33 引文斯高帕斯（Scopus）

摘要

Pyrrolidinyl-camphor derivatives have been proven to be efficient organocatalysts for enantioselective conjugate addition of ketones to alkylidene malonates, affording high chemical yields (up to 95 %) of the corresponding products with high to excellent levels of diastereoselectivity (up to >99:1 dr) and enantioselectivity (up to 96%ee) under solvent-free reaction conditions at ambient temperature.

原文	英語
頁（從 - 到）	2062-2066
頁數	5
期刊	European Journal of Organic Chemistry
發行號	11
DOIs	https://doi.org/10.1002/ejoc.201000072
出版狀態	已發佈 - 2010 4月

ASJC Scopus subject areas

物理與理論化學
有機化學

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abstract = "Pyrrolidinyl-camphor derivatives have been proven to be efficient organocatalysts for enantioselective conjugate addition of ketones to alkylidene malonates, affording high chemical yields (up to 95 %) of the corresponding products with high to excellent levels of diastereoselectivity (up to >99:1 dr) and enantioselectivity (up to 96%ee) under solvent-free reaction conditions at ambient temperature.",

keywords = "Diesters, Enantioselectivity, Ketones, Lactones, Michael addition, Organocatalysis",

author = "Magar, {Dhananjay R.} and Chihliang Chang and Ting, {Ying Fang} and Kwunmin Chen",

year = "2010",

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doi = "10.1002/ejoc.201000072",

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AU - Chang, Chihliang

AU - Ting, Ying Fang

AU - Chen, Kwunmin

PY - 2010/4

Y1 - 2010/4

N2 - Pyrrolidinyl-camphor derivatives have been proven to be efficient organocatalysts for enantioselective conjugate addition of ketones to alkylidene malonates, affording high chemical yields (up to 95 %) of the corresponding products with high to excellent levels of diastereoselectivity (up to >99:1 dr) and enantioselectivity (up to 96%ee) under solvent-free reaction conditions at ambient temperature.

AB - Pyrrolidinyl-camphor derivatives have been proven to be efficient organocatalysts for enantioselective conjugate addition of ketones to alkylidene malonates, affording high chemical yields (up to 95 %) of the corresponding products with high to excellent levels of diastereoselectivity (up to >99:1 dr) and enantioselectivity (up to 96%ee) under solvent-free reaction conditions at ambient temperature.

KW - Diesters

KW - Enantioselectivity

KW - Ketones

KW - Lactones

KW - Michael addition

KW - Organocatalysis

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M3 - Article

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SN - 1434-193X

SP - 2062

EP - 2066

JO - European Journal of Organic Chemistry

JF - European Journal of Organic Chemistry

IS - 11

ER -

Highly enantioselective conjugate addition of ketones to alkylidene malonates catalyzed by a pyrrolidinyl-camphor-derived organocatalyst

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