摘要
A novel, efficient, and unprecedented organocatalytic kinetic resolution has been developed. For the first time, a variety of nitroallylic acetates 1a-i have been resolved with aldehydes in the presence of 2 (2.5 mol %) via conjugate addition-elimination. The densely functionalized products 3a-o were obtained with excellent enantioselectivities (up to >99% ee), and unreacted substrates 1a-i were recovered with good to excellent optical purity (up to 98% ee).
原文 | 英語 |
---|---|
頁(從 - 到) | 1458-1461 |
頁數 | 4 |
期刊 | Organic Letters |
卷 | 13 |
發行號 | 6 |
DOIs | |
出版狀態 | 已發佈 - 2011 3月 18 |
ASJC Scopus subject areas
- 生物化學
- 物理與理論化學
- 有機化學