Highly efficient organocatalytic kinetic resolution of activated nitroallylic acetates with aldehydes via conjugate addition-elimination

Raju Jannapu Reddy, Kwunmin Chen*

*此作品的通信作者

研究成果: 雜誌貢獻期刊論文同行評審

49 引文 斯高帕斯(Scopus)

摘要

A novel, efficient, and unprecedented organocatalytic kinetic resolution has been developed. For the first time, a variety of nitroallylic acetates 1a-i have been resolved with aldehydes in the presence of 2 (2.5 mol %) via conjugate addition-elimination. The densely functionalized products 3a-o were obtained with excellent enantioselectivities (up to >99% ee), and unreacted substrates 1a-i were recovered with good to excellent optical purity (up to 98% ee).

原文英語
頁(從 - 到)1458-1461
頁數4
期刊Organic Letters
13
發行號6
DOIs
出版狀態已發佈 - 2011 三月 18

ASJC Scopus subject areas

  • 生物化學
  • 物理與理論化學
  • 有機化學

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