Gsh-2, a murine homeobox gene expressed in the developing brain

Hsiu Mei Hsieh-Li, David P. Witte, John C. Szucsik, Michael Weinstein, Hung Li, S. Steven Potter*

*此作品的通信作者

研究成果: 雜誌貢獻期刊論文同行評審

76 引文 斯高帕斯(Scopus)

摘要

A novel murine dispersed homeobox gene, designated Gsh-2, is described. Analysis of cDNA sequence, including the full open reading frame, reveals an encoded homeodomain that is surprisingly similar to those of the Antennapedia-type clustered Hox genes. In addition, the encoded protein includes polyhistidine and polyalanine tracts, as observed for several other genes of developmental significance. In situ hybridizations showed Gsh-2 expression in the developing central nervous system, including the ganglionic eminences of the forebrain, the diencephalon, which gives rise to the thalamus and hypothalamus, and in the hindbrain. Furthermore, a random oligonucleotide selection and PCR amplification procedure was used to define a target DNA binding sequence, CNAATTAG, as a first step towards the identification of downstream target genes.

原文英語
頁(從 - 到)177-186
頁數10
期刊Mechanisms of Development
50
發行號2-3
DOIs
出版狀態已發佈 - 1995 4月
對外發佈

ASJC Scopus subject areas

  • 胚胎學
  • 發展生物學

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