Goniothalamin inhibits growth of human lung cancer cells through DNA damage, apoptosis, and reduced migration ability

Chien Chih Chiu, Po Len Liu, Kuang Jing Huang, Hui Min Wang, Kuo Feng Chang, Chon Kit Chou, Fang Rong Chang, Inn Wen Chong, Kang Fang, Jia Shing Chen, Hsueh Wei Chang*, Yang Chang Wu

*此作品的通信作者

研究成果: 雜誌貢獻期刊論文同行評審

69 引文 斯高帕斯(Scopus)

摘要

We evaluated the possible anticancer performance of a natural compound, goniothalamin (GTN), against human lung cancer using as a non-small cell lung cancer (NSCLC) cell line, H1299, as the model system. Cellular proliferation was significantly inhibited by GTN. Using an improved alkaline comet-nuclear extract (comet-NE) assay, GTN was found to induce a significant increase in the tail DNA. Wound healing and zymography assays showed that GTN attenuated cell migration and caused a reduction in the activity level of two major migration-associated matrix metalloproteinases, MMP-2 and MMP-9. It can be concluded that the DNA-damaging effect of GTN against lung cancer cells leads to growth inhibition as well as a depression in migration ability. Therefore, GTN has potential as a chemotherapeutic agent against lung cancer.

原文英語
頁(從 - 到)4288-4293
頁數6
期刊Journal of Agricultural and Food Chemistry
59
發行號8
DOIs
出版狀態已發佈 - 2011 四月 27

ASJC Scopus subject areas

  • 化學 (全部)
  • 農業與生物科學 (全部)

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